/* ===========================================
   BIOLOGICS.CSS - Biologics Helper Styles
   ===========================================

   TABLE OF CONTENTS
   -----------------
   0. Dynamic Class Color System
   1. Biologics Clinician Desktop Layout
   2. Class Selection Grid
   3. Drug Selection Panel
   4. QR Panel & Actions
   5. Patient Mode Styles
   6. Mobile Responsive
   7. Reduced Motion

   =========================================== */


/* ===========================================
   0. DYNAMIC CLASS COLOR SYSTEM
   ===========================================

   When a drug class is selected, the UI transitions
   to that class's color. Uses existing DMARD drug
   colors mapped to biologic classes.

   Uses unified --active-* variables from variables.css.
   Class-specific overrides cascade from body[data-active-class].
   =========================================== */

/* Default state - Pink/Rose (no class selected) */
[data-page="biologics"] {
    --active-color: var(--biologics-base);
    --active-dark: var(--biologics-dark);
    --active-light: var(--biologics-light);
    --active-glow: var(--biologics-glow);
}

/* Class-specific color overrides */
/* TNF Inhibitors - uses MTX color (Celadon) */
[data-page="biologics"][data-active-class="tnf"] {
    --active-color: var(--drug-mtx);
    --active-dark: var(--drug-mtx-dark);
    --active-light: var(--drug-mtx-light);
    --active-glow: var(--drug-mtx-glow);
    --theme-primary: var(--drug-mtx);
    --theme-dark: var(--drug-mtx-dark);
}

/* IL-6 Inhibitors - uses AZA color (Wisteria) */
[data-page="biologics"][data-active-class="il6"] {
    --active-color: var(--drug-aza);
    --active-dark: var(--drug-aza-dark);
    --active-light: var(--drug-aza-light);
    --active-glow: var(--drug-aza-glow);
    --theme-primary: var(--drug-aza);
    --theme-dark: var(--drug-aza-dark);
}

/* B-Cell Depleting - uses LEF color (Slate) */
[data-page="biologics"][data-active-class="bcd"] {
    --active-color: var(--drug-lef);
    --active-dark: var(--drug-lef-dark);
    --active-light: var(--drug-lef-light);
    --active-glow: var(--drug-lef-glow);
    --theme-primary: var(--drug-lef);
    --theme-dark: var(--drug-lef-dark);
}

/* IL-17 Inhibitors - uses TAC color (Tiger's Eye) */
[data-page="biologics"][data-active-class="il17"] {
    --active-color: var(--drug-tac);
    --active-dark: var(--drug-tac-dark);
    --active-light: var(--drug-tac-light);
    --active-glow: var(--drug-tac-glow);
    --theme-primary: var(--drug-tac);
    --theme-dark: var(--drug-tac-dark);
}

/* JAK Inhibitors - uses VCS color (Rhodolite Garnet) */
[data-page="biologics"][data-active-class="jak"] {
    --active-color: var(--drug-vcs);
    --active-dark: var(--drug-vcs-dark);
    --active-light: var(--drug-vcs-light);
    --active-glow: var(--drug-vcs-glow);
    --theme-primary: var(--drug-vcs);
    --theme-dark: var(--drug-vcs-dark);
}

/* Other - uses MMF color (Rosewood) */
[data-page="biologics"][data-active-class="other"] {
    --active-color: var(--drug-mmf);
    --active-dark: var(--drug-mmf-dark);
    --active-light: var(--drug-mmf-light);
    --active-glow: var(--drug-mmf-glow);
    --theme-primary: var(--drug-mmf);
    --theme-dark: var(--drug-mmf-dark);
}

/* IL-12/23 Inhibitors - uses SSZ color (Rust/Terracotta) */
[data-page="biologics"][data-active-class="il1223"] {
    --active-color: var(--drug-ssz);
    --active-dark: var(--drug-ssz-dark);
    --active-light: var(--drug-ssz-light);
    --active-glow: var(--drug-ssz-glow);
    --theme-primary: var(--drug-ssz);
    --theme-dark: var(--drug-ssz-dark);
}

/* Bone Agents - uses CIC color (Teal) */
[data-page="biologics"][data-active-class="bone"] {
    --active-color: var(--drug-cic);
    --active-dark: var(--drug-cic-dark);
    --active-light: var(--drug-cic-light);
    --active-glow: var(--drug-cic-glow);
    --theme-primary: var(--drug-cic);
    --theme-dark: var(--drug-cic-dark);
}


/* === BIOLOGICS-SPECIFIC ELEMENT OVERRIDES === */

/* Nav pill indicator */
[data-page="biologics"] .nav-pill-indicator:not(.calc-preview) {
    background: var(--active-color);
    transition: transform 380ms cubic-bezier(0.22, 1, 0.36, 1),
                width 280ms cubic-bezier(0.22, 1, 0.36, 1),
                background-color 200ms ease-out;
}

/* Card header icon */
[data-page="biologics"] .card-header .icon {
    color: var(--active-color);
    transition: color 200ms ease-out;
}

/* Primary button */
[data-page="biologics"] .btn-primary {
    background: var(--active-color);
    transition: background 200ms ease-out, transform var(--transition-fast), box-shadow var(--transition-fast);
}

@media (any-hover: hover) {
    [data-page="biologics"] .btn-primary:hover {
        background: var(--active-dark);
    }

    [data-page="biologics"] .btn-secondary-outline:hover {
        border-color: var(--active-color);
        background: var(--active-light);
        color: var(--active-color);
    }
}

[data-page="biologics"] .btn-primary:active {
    background: var(--active-dark);
}

[data-page="biologics"] .btn-secondary-outline:active {
    border-color: var(--active-color);
    background: var(--active-light);
    color: var(--active-color);
}

/* Theme toggle */
[data-page="biologics"] .theme-toggle::before,
[data-page="biologics"] .mobile-theme-toggle::before {
    background: var(--active-color);
    transition: transform var(--duration-entrance) var(--ease-out-back),
                background-color 200ms ease-out;
}

[data-page="biologics"] .theme-toggle:hover,
[data-page="biologics"] .mobile-theme-toggle:hover {
    border-color: var(--active-color);
}

/* Header branding */
[data-page="biologics"] .header-brand::before {
    background: var(--active-color);
    transition: background 200ms ease-out;
}

[data-page="biologics"] .header-subtitle,
[data-page="biologics"] .subtitle-separator {
    color: var(--active-color);
    transition: color 200ms ease-out;
}

/* Page title when class selected */
[data-page="biologics"][data-active-class] .page-title {
    color: var(--active-color);
    transition: color 200ms ease-out;
}


/* ===========================================
   1. BIOLOGICS CLINICIAN DESKTOP LAYOUT
   =========================================== */

.biologics-card {
    scroll-margin-top: 10px;
}

/* Section labels - global styles */
.biologics-section-label {
    display: flex;
    align-items: center;
    font-size: 0.75rem;
    font-weight: 600;
    text-transform: uppercase;
    letter-spacing: 0.05em;
    color: var(--text-muted);
    margin: 0 0 0.75rem 0;
}

.biologics-section-label:not(:first-of-type) {
    margin-top: 0.5rem;
}

@media (min-width: 900px) {
    [data-page="biologics"] .page-content {
        max-width: var(--layout-medium);
        padding: 3rem 2rem;
        padding-top: calc(var(--header-height) + 3rem);
        flex: 0 1 auto;
    }

    .biologics-clinician-mode {
        max-width: 1100px;
    }

    .biologics-clinician-layout {
        display: grid;
        grid-template-columns: 1fr 320px;
        gap: 2rem;
        align-items: start;
    }

    .biologics-clinician-steps {
        display: flex;
        flex-direction: column;
        gap: 1.25rem;
    }

    /* First card accent border */
    .biologics-clinician-layout .biologics-clinician-steps > .card:first-child {
        border-top: 3px solid var(--active-color);
        transition: border-top-color 200ms ease-out;
    }

    .clinician-output {
        align-self: start;
    }

    .biologics-clinician-mode .card {
        padding: 1.25rem;
        margin-bottom: 0;
    }

    .biologics-clinician-mode .biologics-card .card-header {
        margin-bottom: 1rem;
        padding-bottom: 0.75rem;
    }

    .biologics-clinician-mode .biologics-card .card-header h2 {
        font-size: 0.95rem;
    }
}


/* ===========================================
   2. CLASS SELECTION - GHOST/OUTLINE STYLE
   =========================================== */

.biologics-class-grid {
    display: grid;
    grid-template-columns: repeat(4, 1fr);
    gap: 0.5rem;
}

.biologics-class-btn {
    display: flex;
    align-items: center;
    justify-content: center;
    text-align: center;
    padding: 0.875rem 0.75rem;
    height: 56px;
    border-radius: var(--radius-md);
    border: 2px solid var(--class-color, var(--border-color));
    background: color-mix(in srgb, var(--class-light, rgba(0, 0, 0, 0.03)) 75%, transparent);
    color: var(--text-primary);
    font-size: 0.85rem;
    font-weight: 600;
    cursor: pointer;
    transition: all var(--transition-fast);
}

.biologics-class-btn .class-name {
    font-weight: 600;
    font-size: 0.85rem;
    line-height: 1.2;
}

/* Desktop: show full name only, hide abbreviation */
.biologics-class-btn .class-abbrev {
    display: none;
}

/* Hover state */
@media (any-hover: hover) {
    .biologics-class-btn:hover:not(.selected) {
        background: var(--class-light, var(--biologics-light));
        border-color: var(--class-color, var(--biologics-base));
    }
}

/* Selected state - filled with class color */
.biologics-class-btn.selected {
    background: var(--class-color, var(--biologics-base));
    border-color: var(--class-color, var(--biologics-base));
    color: white;
    box-shadow: 0 0 16px var(--class-glow, var(--biologics-glow));
}

.biologics-class-btn.selected .class-name,
.biologics-class-btn.selected .class-abbrev {
    color: white;
}

/* Visual hierarchy - unselected buttons recede when one is selected */
.biologics-card[data-active-class] .biologics-class-btn:not(.selected) {
    opacity: 0.5;
}

.biologics-card[data-active-class] .biologics-class-btn:not(.selected):hover {
    opacity: 0.85;
}

/* Class-specific colors via CSS variables on the element */
.biologics-class-btn[data-class="tnf"] {
    --class-color: var(--drug-mtx);
    --class-light: var(--drug-mtx-light);
    --class-glow: var(--drug-mtx-glow);
}
.biologics-class-btn[data-class="il6"] {
    --class-color: var(--drug-aza);
    --class-light: var(--drug-aza-light);
    --class-glow: var(--drug-aza-glow);
}
.biologics-class-btn[data-class="bcd"] {
    --class-color: var(--drug-lef);
    --class-light: var(--drug-lef-light);
    --class-glow: var(--drug-lef-glow);
}
.biologics-class-btn[data-class="il17"] {
    --class-color: var(--drug-tac);
    --class-light: var(--drug-tac-light);
    --class-glow: var(--drug-tac-glow);
}
.biologics-class-btn[data-class="jak"] {
    --class-color: var(--drug-vcs);
    --class-light: var(--drug-vcs-light);
    --class-glow: var(--drug-vcs-glow);
}
.biologics-class-btn[data-class="other"] {
    --class-color: var(--drug-mmf);
    --class-light: var(--drug-mmf-light);
    --class-glow: var(--drug-mmf-glow);
}
.biologics-class-btn[data-class="il1223"] {
    --class-color: var(--drug-ssz);
    --class-light: var(--drug-ssz-light);
    --class-glow: var(--drug-ssz-glow);
}
.biologics-class-btn[data-class="bone"] {
    --class-color: var(--drug-cic);
    --class-light: var(--drug-cic-light);
    --class-glow: var(--drug-cic-glow);
}


/* ===========================================
   STEP BADGES - Color on selection
   =========================================== */

/* Step 1: Class badge colors when class is selected */
.biologics-card[data-active-class] .step-badge--class {
    background: var(--active-color);
    color: white;
    box-shadow: 0 0 8px var(--active-glow);
    border-color: var(--active-color);
    transition: background 200ms ease-out, box-shadow 200ms ease-out;
}

/* Step 2: Drug badge colors when drug is selected */
.biologics-drug-panel[data-active-drug] .step-badge--drug {
    background: var(--active-color);
    color: white;
    box-shadow: 0 0 8px var(--active-glow);
    border-color: var(--active-color);
    transition: background 200ms ease-out, box-shadow 200ms ease-out;
}


/* ===========================================
   3. DRUG SELECTION PANEL
   =========================================== */

.biologics-drug-panel {
    margin-top: 1rem;
    padding-top: 1rem;
    border-top: 1px solid var(--border-color);
    animation: fadeSlideIn 250ms ease-out;
}

@keyframes fadeSlideIn {
    from {
        opacity: 0;
        transform: translateY(-8px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

.biologics-drug-panel-label {
    font-size: 0.75rem;
    font-weight: 600;
    text-transform: uppercase;
    letter-spacing: 0.05em;
    color: var(--text-muted);
    margin-bottom: 0.75rem;
}

.biologics-drug-grid {
    display: flex;
    flex-wrap: nowrap;
    gap: 0.5rem;
}

/* === PYRAMID LAYOUTS FOR DIFFERENT DRUG COUNTS (Desktop only) === */
@media (min-width: 900px) {
    .biologics-drug-grid {
        display: grid;
        grid-template-columns: repeat(6, 1fr);
        row-gap: 0.75rem;
        align-items: start;
    }

    /* Smaller font for 5-drug grids (TNF Inhibitors) */
    .biologics-drug-grid:has(.select-btn:nth-child(5):last-child) .drug-name {
        font-size: 0.9em;
    }

    /* 1 drug - centered (narrower card) */
    .biologics-drug-grid:has(.select-btn:nth-child(1):last-child) .select-btn:nth-child(1) {
        grid-column: 2 / 5;
    }

    /* 2 drugs - centered side by side */
    .biologics-drug-grid:has(.select-btn:nth-child(2):last-child) .select-btn:nth-child(1) {
        grid-column: 1 / 4;
    }
    .biologics-drug-grid:has(.select-btn:nth-child(2):last-child) .select-btn:nth-child(2) {
        grid-column: 4 / 7;
    }

    /* 3 drugs - single row */
    .biologics-drug-grid:has(.select-btn:nth-child(3):last-child) .select-btn:nth-child(1) {
        grid-column: 1 / 3;
    }
    .biologics-drug-grid:has(.select-btn:nth-child(3):last-child) .select-btn:nth-child(2) {
        grid-column: 3 / 5;
    }
    .biologics-drug-grid:has(.select-btn:nth-child(3):last-child) .select-btn:nth-child(3) {
        grid-column: 5 / 7;
    }

    /* 4 drugs - 2x2 grid */
    .biologics-drug-grid:has(.select-btn:nth-child(4):last-child) .select-btn:nth-child(1) {
        grid-column: 1 / 4;
    }
    .biologics-drug-grid:has(.select-btn:nth-child(4):last-child) .select-btn:nth-child(2) {
        grid-column: 4 / 7;
    }
    .biologics-drug-grid:has(.select-btn:nth-child(4):last-child) .select-btn:nth-child(3) {
        grid-column: 1 / 4;
    }
    .biologics-drug-grid:has(.select-btn:nth-child(4):last-child) .select-btn:nth-child(4) {
        grid-column: 4 / 7;
    }

    /* 5 drugs - pyramid (3 + 2 centered) */
    .biologics-drug-grid:has(.select-btn:nth-child(5):last-child) .select-btn:nth-child(1) {
        grid-column: 1 / 3;
    }
    .biologics-drug-grid:has(.select-btn:nth-child(5):last-child) .select-btn:nth-child(2) {
        grid-column: 3 / 5;
    }
    .biologics-drug-grid:has(.select-btn:nth-child(5):last-child) .select-btn:nth-child(3) {
        grid-column: 5 / 7;
    }
    .biologics-drug-grid:has(.select-btn:nth-child(5):last-child) .select-btn:nth-child(4) {
        grid-column: 2 / 4;
    }
    .biologics-drug-grid:has(.select-btn:nth-child(5):last-child) .select-btn:nth-child(5) {
        grid-column: 4 / 6;
    }
}

/* === BIOLOGICS DRUG BUTTON OVERRIDES === */
/* Base styling inherited from .select-btn in components.css */

.biologics-drug-grid .select-btn {
    border-left: 4px solid var(--active-color);
    position: relative;
}

/* Hide mobile-only elements on desktop */
.biologics-drug-grid .select-btn > .drug-abbrev,
.biologics-drug-grid .select-btn > .route-dot,
.biologics-drug-grid .select-btn > .mobile-expanded-content {
    display: none;
}

/* Desktop: fixed height and grid fallback */
@media (min-width: 900px) {
    .biologics-drug-grid .select-btn {
        grid-column: span 2; /* Default for 6+ drugs fallback */
        height: 64px;
    }
}

/* Desktop: show full name only */
.biologics-drug-grid .select-btn .drug-abbrev {
    display: none;
}

/* Biologics drug button hover - tint background and solidify left border */
@media (any-hover: hover) {
    .biologics-drug-grid .select-btn[data-drug]:not(.selected):hover {
        background: var(--active-light);
        border-left-color: var(--active-color);
    }
}

/* Biologics-specific selected state - uses active class color */
/* Note: [data-drug] matches DMARD pattern for specificity to override components.css */
[data-page="biologics"] .select-btn[data-drug].selected {
    background: var(--active-color);
    border-left-width: var(--drug-edge-width);
    border-left-color: var(--active-dark);
    color: white;
    box-shadow: var(--drug-edge-inset), var(--shadow-md), 0 0 0 3px var(--active-light);
}

/* Visual hierarchy when drug selected */
.biologics-drug-panel[data-active-drug] .select-btn:not(.selected) {
    opacity: 0.55;
    transform: scale(0.98);
}

.biologics-drug-panel[data-active-drug] .select-btn:not(.selected):hover {
    opacity: 0.85;
    transform: scale(1);
}


/* ===========================================
   ROUTE BADGES & EXPANSION PANEL (Desktop only)
   =========================================== */

/* Drug card content layout - desktop */
@media (min-width: 900px) {
    .biologics-drug-grid .select-btn {
        flex-direction: column;
        align-items: stretch;
        justify-content: flex-start;
        height: 64px;
        padding: 0.625rem 0.75rem;
        overflow: hidden;
        transition: height 0.25s ease, box-shadow 0.15s ease, transform 0.15s ease, background-color 0.15s ease, border-color 0.15s ease;
    }

    /* Allow expanded cards to grow - use specific height for smooth animation */
    .biologics-drug-grid .select-btn.expanded {
        height: 140px;
        overflow: visible;
    }

    .biologics-drug-grid .select-btn .drug-card-content {
        display: flex;
        align-items: flex-start;
        justify-content: space-between;
        gap: 0.5rem;
        width: 100%;
    }

    .biologics-drug-grid .select-btn .drug-info {
        display: flex;
        flex-direction: column;
        gap: 0.125rem;
        text-align: left;
    }

    .biologics-drug-grid .select-btn .drug-name {
        display: block;
        font-weight: 600;
        font-size: 0.95rem;
    }

    .biologics-drug-grid .select-btn .drug-info .drug-abbrev {
        display: block;
        font-size: 0.7rem;
        color: var(--text-muted);
    }

    .biologics-drug-grid .select-btn.selected .drug-info .drug-abbrev {
        color: rgba(255, 255, 255, 0.7);
    }
}

/* Route badges container */
.route-badges {
    display: none; /* Hidden on mobile */
}

@media (min-width: 900px) {
    .route-badges {
        display: flex;
        gap: 0.25rem;
        flex-shrink: 0;
    }

    .route-badges.single-route .route-badge {
        opacity: 0.75;
    }
}

/* Individual route badge */
.route-badge {
    font-family: var(--font-mono);
    font-size: 0.6rem;
    font-weight: 500;
    padding: 0.15rem 0.35rem;
    border-radius: 4px;
    letter-spacing: 0.02em;
    line-height: 1;
    cursor: pointer;
    transition: transform 0.1s ease, opacity 0.1s ease;
}

@media (any-hover: hover) {
    .route-badge:hover {
        transform: scale(1.1);
        opacity: 1 !important;
    }
}

/* Route-specific colors */
.route-badge.sc {
    background: var(--route-sc-bg);
    color: var(--route-sc);
}

.route-badge.iv {
    background: var(--route-iv-bg);
    color: var(--route-iv);
}

.route-badge.po {
    background: var(--route-po-bg);
    color: var(--route-po);
}

/* When drug is selected, badges use inverted colors */
.biologics-drug-grid .select-btn.selected .route-badge {
    background: rgba(255, 255, 255, 0.15);
    color: rgba(255, 255, 255, 0.6);
}

/* Active route badge has stronger presence */
.biologics-drug-grid .select-btn.selected .route-badge.active {
    background: rgba(255, 255, 255, 0.3);
    color: white;
    box-shadow: 0 0 0 1px rgba(255, 255, 255, 0.4);
}

/* === ROUTE EXPANSION PANEL === */
.route-expansion {
    display: grid;
    grid-template-rows: 0fr;
    height: 0;
    overflow: hidden;
    transition: grid-template-rows 0.25s ease, height 0.25s ease, margin-top 0.25s ease;
    margin-top: 0;
    width: 100%;
}

/* Only expand when card is BOTH selected AND expanded */
.select-btn.selected.expanded .route-expansion {
    grid-template-rows: 1fr;
    height: auto;
    margin-top: 0.75rem;
}

.route-expansion-inner {
    overflow: hidden;
    min-height: 0; /* Required for grid collapse */
}

.route-selector {
    display: flex;
    gap: 0.5rem;
    padding-top: 0.75rem;
    border-top: 1px solid var(--border-subtle);
    transition: border-top-color 0.25s ease;
}

/* When card is selected, use lighter border for expansion */
.select-btn.selected .route-selector {
    border-top-color: rgba(255, 255, 255, 0.2);
}

/* Route option buttons (using div with role="button") */
.route-option {
    flex: 1;
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: 0.25rem;
    padding: 0.625rem 0.5rem;
    border-radius: var(--radius-sm);
    border: 2px solid var(--border-color);
    background: var(--bg-secondary);
    cursor: pointer;
    transition: all 0.15s ease;
    font-family: inherit;
    user-select: none;
}

/* When card is selected, option buttons need adjusted colors */
.select-btn.selected .route-option {
    border-color: rgba(255, 255, 255, 0.25);
    background: rgba(255, 255, 255, 0.1);
}

.route-option-label {
    font-family: var(--font-mono);
    font-size: 0.75rem;
    font-weight: 600;
}

.route-option-desc {
    font-size: 0.65rem;
    color: var(--text-muted);
}

.select-btn.selected .route-option-desc {
    color: rgba(255, 255, 255, 0.6);
}

/* Route option active states */
.route-option.active {
    border-width: 2px;
}

.route-option.sc.active {
    border-color: var(--route-sc);
    background: var(--route-sc-bg);
}

.route-option.sc.active .route-option-label {
    color: var(--route-sc);
}

.route-option.iv.active {
    border-color: var(--route-iv);
    background: var(--route-iv-bg);
}

.route-option.iv.active .route-option-label {
    color: var(--route-iv);
}

.route-option.po.active {
    border-color: var(--route-po);
    background: var(--route-po-bg);
}

.route-option.po.active .route-option-label {
    color: var(--route-po);
}

/* When card is selected, active route option uses white text */
.select-btn.selected .route-option.active {
    background: rgba(255, 255, 255, 0.25);
    border-color: white;
}

.select-btn.selected .route-option.active .route-option-label,
.select-btn.selected .route-option.active .route-option-desc {
    color: white;
}

/* Hover states for route options */
@media (any-hover: hover) {
    .route-option:not(.active):hover {
        border-color: var(--text-muted);
        background: var(--bg-surface);
    }

    .select-btn.selected .route-option:not(.active):hover {
        border-color: rgba(255, 255, 255, 0.5);
        background: rgba(255, 255, 255, 0.15);
    }
}


/* ===========================================
   4. QR PANEL & ACTIONS
   Desktop uses shared .qr-output-panel from components.css
   =========================================== */

/* QR container base styles */
#biologics-qr-container {
    display: inline-flex;
    align-items: center;
    justify-content: center;
    background: white;
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-sm);
    position: relative;
}

/* Desktop QR container - hero size to match DMARD */
@media (min-width: 901px) {
    #biologics-qr-container {
        padding: 0.875rem;
        min-height: 248px; /* 220px QR + padding */
        min-width: 248px;
    }

    /* Default QR glow (pink) + reveal animation */
    .qr-output-panel.qr-ready #biologics-qr-container {
        box-shadow: var(--shadow-md), 0 0 20px var(--biologics-glow);
        animation: qrRevealCelebrate 350ms var(--ease-out-back);
    }

    /* Class-specific QR glow colors */
    .qr-output-panel.qr-ready[data-active-class="tnf"] #biologics-qr-container {
        box-shadow: var(--shadow-md), 0 0 20px var(--drug-mtx-glow);
    }
    .qr-output-panel.qr-ready[data-active-class="il6"] #biologics-qr-container {
        box-shadow: var(--shadow-md), 0 0 20px var(--drug-aza-glow);
    }
    .qr-output-panel.qr-ready[data-active-class="bcd"] #biologics-qr-container {
        box-shadow: var(--shadow-md), 0 0 20px var(--drug-lef-glow);
    }
    .qr-output-panel.qr-ready[data-active-class="il17"] #biologics-qr-container {
        box-shadow: var(--shadow-md), 0 0 20px var(--drug-tac-glow);
    }
    .qr-output-panel.qr-ready[data-active-class="jak"] #biologics-qr-container {
        box-shadow: var(--shadow-md), 0 0 20px var(--drug-vcs-glow);
    }
    .qr-output-panel.qr-ready[data-active-class="tcm"] #biologics-qr-container {
        box-shadow: var(--shadow-md), 0 0 20px var(--drug-mmf-glow);
    }
    .qr-output-panel.qr-ready[data-active-class="il1223"] #biologics-qr-container {
        box-shadow: var(--shadow-md), 0 0 20px var(--drug-ssz-glow);
    }
    .qr-output-panel.qr-ready[data-active-class="bone"] #biologics-qr-container {
        box-shadow: var(--shadow-md), 0 0 20px var(--drug-cic-glow);
    }
}

/* === QR RESET ICON BUTTON === */
[data-page="biologics"] .qr-reset-icon-btn {
    color: var(--text-muted);
    transition: color 150ms ease-out, background 150ms ease-out;
}

@media (any-hover: hover) {
    [data-page="biologics"] .qr-reset-icon-btn:hover {
        color: var(--active-color);
        background: var(--active-light);
    }
}

/* QR code active/pressed - override animation transform */
[data-page="biologics"] .qr-output-panel .qr-container-clickable:active,
[data-page="biologics"] .biologics-mobile-card .qr-container-clickable:active,
[data-page="biologics"] .qr-output-panel .qr-container-clickable.pressing,
[data-page="biologics"] .biologics-mobile-card .qr-container-clickable.pressing {
    transform: scale(0.97);
    animation: none;
}

/* Celebratory QR reveal animation */
@keyframes qrRevealCelebrate {
    0% {
        opacity: 0;
        transform: scale(0.92);
    }
    60% {
        opacity: 1;
        transform: scale(1.02);
    }
    100% {
        opacity: 1;
        transform: scale(1);
    }
}

/* Subtle QR dismiss animation - for contextual clearing (e.g., class change) */
.qr-output-panel.qr-dismissing #biologics-qr-container,
.biologics-mobile-card.qr-dismissing #biologics-qr-container {
    animation: qrDismiss 200ms ease-in forwards;
}

@keyframes qrDismiss {
    from {
        opacity: 1;
        transform: scale(1);
    }
    to {
        opacity: 0;
        transform: scale(0.92);
    }
}

/* Mobile QR section */
@media (max-width: 900px) {
    .biologics-mobile-qr-section {
        position: relative;
        text-align: center;
        margin-top: 1rem;
        padding-top: 1rem;
        border-top: 1px solid var(--border-color);
    }

    /* QR Placeholder - mobile version */
    .biologics-mobile-qr-section .qr-placeholder-mobile {
        background: linear-gradient(135deg, var(--bg-primary), var(--bg-secondary));
        border: 2px dashed var(--border-color);
        border-radius: var(--radius-lg);
        padding: 2rem 1rem;
        color: var(--text-muted);
        font-size: 0.8rem;
        line-height: 1.4;
        animation: breathe var(--duration-breathing) ease-in-out infinite;
        min-height: 180px;
        display: flex;
        flex-direction: column;
        align-items: center;
        justify-content: center;
    }

    .biologics-mobile-qr-section .qr-placeholder-mobile .qr-placeholder-icon {
        margin-bottom: 0.5rem;
        opacity: 0.35;
        animation: breatheIcon var(--duration-breathing) ease-in-out infinite;
    }

    .biologics-mobile-qr-section .qr-placeholder-mobile .qr-placeholder-icon svg {
        width: 40px;
        height: 40px;
    }

    /* QR content wrapper - mobile */
    .biologics-mobile-qr-section .qr-content-mobile {
        display: none;
    }

    .biologics-mobile-card.qr-ready .qr-placeholder-mobile {
        display: none;
    }

    .biologics-mobile-card.qr-ready .qr-content-mobile {
        display: block;
    }

    /* Prevent refresh icon from inheriting animation on reveal */
    .qr-content-mobile .qr-reset-icon-btn svg {
        animation: none;
    }
    .qr-content-mobile .qr-reset-icon-btn svg.icon-spin {
        animation: iconSpinOnce var(--duration-entrance) cubic-bezier(0.4, 0, 0.2, 1);
    }

    /* Hide QR container when empty */
    #biologics-qr-container:empty {
        opacity: 0;
    }

    /* QR container - mobile */
    .biologics-mobile-qr-section #biologics-qr-container {
        padding: 0.625rem;
        margin-bottom: 0;
        min-height: 176px;
        min-width: 176px;
    }

    /* QR glow on mobile - default pink */
    .biologics-mobile-card.qr-ready #biologics-qr-container {
        box-shadow: var(--shadow-md), 0 0 16px var(--biologics-glow);
        animation: qrRevealCelebrate 350ms var(--ease-out-back);
    }

    /* Class-specific QR glow colors on mobile */
    .biologics-mobile-card.qr-ready[data-active-class="tnf"] #biologics-qr-container {
        box-shadow: var(--shadow-md), 0 0 16px var(--drug-mtx-glow);
    }
    .biologics-mobile-card.qr-ready[data-active-class="il6"] #biologics-qr-container {
        box-shadow: var(--shadow-md), 0 0 16px var(--drug-aza-glow);
    }
    .biologics-mobile-card.qr-ready[data-active-class="bcd"] #biologics-qr-container {
        box-shadow: var(--shadow-md), 0 0 16px var(--drug-lef-glow);
    }
    .biologics-mobile-card.qr-ready[data-active-class="il17"] #biologics-qr-container {
        box-shadow: var(--shadow-md), 0 0 16px var(--drug-tac-glow);
    }
    .biologics-mobile-card.qr-ready[data-active-class="jak"] #biologics-qr-container {
        box-shadow: var(--shadow-md), 0 0 16px var(--drug-vcs-glow);
    }
    .biologics-mobile-card.qr-ready[data-active-class="tcm"] #biologics-qr-container {
        box-shadow: var(--shadow-md), 0 0 16px var(--drug-mmf-glow);
    }
    .biologics-mobile-card.qr-ready[data-active-class="il1223"] #biologics-qr-container {
        box-shadow: var(--shadow-md), 0 0 16px var(--drug-ssz-glow);
    }
    .biologics-mobile-card.qr-ready[data-active-class="bone"] #biologics-qr-container {
        box-shadow: var(--shadow-md), 0 0 16px var(--drug-cic-glow);
    }

    /* Mobile tap depression - needs ID specificity to override animation */
    .biologics-mobile-card #biologics-qr-container:active,
    .biologics-mobile-card #biologics-qr-container.pressing {
        transform: scale(0.97);
        animation: none;
    }

    /* Animation states */
    .biologics-mobile-card.resetting .qr-content-mobile {
        opacity: 0;
        transform: scale(0.95);
        transition: opacity var(--duration-base) ease-out, transform var(--duration-base) ease-out;
    }

    .biologics-mobile-card.reset-complete .qr-placeholder-mobile {
        animation: placeholderReturn var(--transition-entrance);
    }
}


/* ===========================================
   5. PATIENT MODE STYLES
   =========================================== */

.biologics-patient-mode {
    max-width: var(--layout-narrow);
    margin: 0 auto;
    padding: 1.5rem 1rem;
}

/* Patient summary bar */
.biologics-patient-summary {
    display: flex;
    align-items: center;
    gap: 0.75rem;
    padding: 1rem 1.25rem;
    background: var(--active-light);
    border-left: 4px solid var(--active-color);
    border-radius: var(--radius-md);
    margin-bottom: 1.5rem;
}

.biologics-patient-summary .summary-icon {
    width: 32px;
    height: 32px;
    color: var(--active-color);
}

.biologics-patient-summary .summary-text {
    flex: 1;
}

.biologics-patient-summary .drug-name {
    font-weight: 600;
    color: var(--text-primary);
    font-size: 1rem;
}

.biologics-patient-summary .drug-class {
    font-size: 0.875rem;
    color: var(--text-secondary);
}

/* ===========================================
   PATIENT VIEW - INFO SECTIONS
   =========================================== */

/* PDF link card - border and icon color */
[data-page="biologics"] .pdf-link-card {
    border-left-color: var(--active-color);
    margin-bottom: 1rem;
    transition: transform var(--transition-fast), box-shadow var(--transition-fast), border-left-color 200ms ease-out;
}

[data-page="biologics"] .pdf-link-card svg {
    color: var(--active-color);
    transition: color 200ms ease-out;
}

/* Contact card section spacing */
[data-page="biologics"] .contact-card-section {
    margin-bottom: 1rem;
}

/* Info sections (Next Steps, Vaccinations, Once Started) */
[data-page="biologics"] .info-section {
    margin-bottom: 1rem;
}

[data-page="biologics"] .info-section .card-header {
    display: flex;
    align-items: center;
    gap: 0.75rem;
    padding-bottom: 0.75rem;
    margin-bottom: 0.75rem;
    border-bottom: 1px solid rgba(0, 0, 0, 0.12);
}

/* Dark mode: more visible divider */
[data-theme="dark"][data-page="biologics"] .info-section .card-header {
    border-bottom-color: rgba(255, 255, 255, 0.15);
}

[data-page="biologics"] .info-section .card-header .icon {
    width: 22px;
    height: 22px;
    color: var(--active-color);
}

[data-page="biologics"] .info-section .card-header h2 {
    font-size: 1rem;
    font-weight: 600;
    color: var(--text-primary);
    margin: 0;
}

[data-page="biologics"] .info-content {
    font-size: 0.9375rem;
    line-height: 1.6;
    color: var(--text-secondary);
}

[data-page="biologics"] .info-content p {
    margin: 0 0 0.75rem;
}

[data-page="biologics"] .info-content p:last-child {
    margin-bottom: 0;
}

/* Highlight note (warning/attention style) */
[data-page="biologics"] .highlight-note {
    display: flex;
    align-items: flex-start;
    gap: 0.5rem;
    padding: 0.75rem 1rem;
    background: var(--accent-warning-light, #fff8e6);
    border-radius: var(--radius-sm);
    color: var(--accent-warning-dark, #8a6d3b);
    font-size: 0.875rem;
    margin-top: 0.75rem;
}

[data-page="biologics"] .highlight-note svg {
    flex-shrink: 0;
    width: 16px;
    height: 16px;
    margin-top: 2px;
}

/* Warning variant (red/danger) */
[data-page="biologics"] .highlight-note.warning {
    background: var(--accent-danger);
    border-color: var(--accent-danger-border);
    color: var(--accent-danger-text);
}

/* ===========================================
   PROCESS TIMELINE
   =========================================== */

/* Timeline wrapper for layout control */
[data-page="biologics"] .timeline-wrapper {
    margin-bottom: 1rem;
}

[data-page="biologics"] .process-timeline {
    display: flex;
    justify-content: space-between;
    align-items: flex-start;
    position: relative;
    padding: 0 0.5rem;
    margin: 0.5rem 0 0.75rem;
}

/* Connecting line behind steps */
[data-page="biologics"] .timeline-track {
    position: absolute;
    top: 15px;
    left: calc(10% + 15px);
    right: calc(10% + 15px);
    height: 2px;
    background: var(--border-color);
    z-index: 0;
}

[data-page="biologics"] .timeline-step {
    display: flex;
    flex-direction: column;
    align-items: center;
    flex: 1;
    position: relative;
    z-index: 1;
}

[data-page="biologics"] .step-marker {
    width: 30px;
    height: 30px;
    border-radius: 50%;
    background: var(--bg-secondary);
    border: 2px solid var(--border-color);
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 0.75rem;
    font-weight: 600;
    color: var(--text-muted);
    margin-bottom: 0.5rem;
    transition: all 0.3s ease;
}

[data-page="biologics"] .step-label {
    font-size: 0.75rem;
    color: var(--text-muted);
    text-align: center;
    font-weight: 500;
    transition: color 0.3s ease;
}

/* Active step styling */
[data-page="biologics"] .timeline-step.active .step-marker {
    /* Layer transparent active color over solid background to hide the track line */
    background:
        linear-gradient(var(--active-light), var(--active-light)),
        var(--bg-secondary);
    border-color: var(--active-color);
    color: var(--active-color);
    animation: gentle-pulse 2.5s ease-in-out infinite;
}

[data-page="biologics"] .timeline-step.active .step-label {
    color: var(--active-color);
    font-weight: 600;
}

/* Completed steps (future enhancement) */
[data-page="biologics"] .timeline-step.completed .step-marker {
    background: var(--active-color);
    border-color: var(--active-color);
    color: white;
}

[data-page="biologics"] .timeline-step.completed .step-label {
    color: var(--text-secondary);
}

/* Gentle pulse animation for active step */
@keyframes gentle-pulse {
    0%, 100% {
        box-shadow: 0 0 0 0 var(--active-glow);
    }
    50% {
        box-shadow: 0 0 0 6px transparent;
    }
}

/* Timeline description */
[data-page="biologics"] .timeline-description {
    color: var(--text-secondary);
    margin: 0 0 0.75rem 0;
}

[data-page="biologics"] .timeline-duration {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 0.375rem;
    font-size: 0.875rem;
    color: var(--text-muted);
    margin: 0;
}

[data-page="biologics"] .timeline-duration svg {
    width: 14px;
    height: 14px;
    opacity: 0.7;
}

[data-page="biologics"] .timeline-duration strong {
    color: var(--text-muted);
    text-decoration: underline;
    text-decoration-color: var(--active-color);
    text-underline-offset: 2px;
}

/* Contact card followup note */
[data-page="biologics"] .contact-followup {
    margin-top: 0.75rem;
    padding-top: 0.75rem;
    border-top: 1px solid var(--border-subtle);
    font-size: 0.875rem;
    font-style: italic;
    color: var(--text-muted);
}

/* Vaccine list */
[data-page="biologics"] .vaccine-list {
    list-style: none;
    padding: 0;
    margin: 0.5rem 0 0;
}

[data-page="biologics"] .vaccine-list li {
    padding: 0.375rem 0;
    padding-left: 1.25rem;
    position: relative;
}

[data-page="biologics"] .vaccine-list li::before {
    content: '';
    position: absolute;
    left: 0;
    top: 0.75rem;
    width: 6px;
    height: 6px;
    background: var(--active-color);
    border-radius: 50%;
}

[data-page="biologics"] .vaccine-list li strong {
    color: var(--text-primary);
}

[data-page="biologics"] .vaccine-note {
    margin-top: 1rem;
    padding-top: 0.75rem;
    border-top: 1px solid var(--border-subtle);
    font-size: 0.875rem;
    font-style: italic;
    color: var(--text-muted);
}

/* Guidance list (dental health bullets) */
[data-page="biologics"] .guidance-list {
    list-style: none;
    padding: 0;
    margin: 0.5rem 0 0;
}

[data-page="biologics"] .guidance-list li {
    padding: 0.375rem 0;
    padding-left: 1.25rem;
    position: relative;
    font-size: 0.875rem;
}

[data-page="biologics"] .guidance-list li::before {
    content: '';
    position: absolute;
    left: 0;
    top: 0.7rem;
    width: 6px;
    height: 6px;
    background: var(--active-color);
    border-radius: 50%;
}

/* Warning list (watch for symptoms) */
[data-page="biologics"] .warning-list {
    list-style: none;
    padding: 0;
    margin: 0.5rem 0 0;
}

[data-page="biologics"] .warning-list li {
    padding: 0.5rem 0;
    padding-left: 1.25rem;
    position: relative;
    font-size: 0.875rem;
    border-bottom: 1px solid var(--border-subtle);
}

[data-page="biologics"] .warning-list li:last-child {
    border-bottom: none;
}

[data-page="biologics"] .warning-list li::before {
    content: '!';
    position: absolute;
    left: 0;
    top: 0.5rem;
    width: 14px;
    height: 14px;
    background: var(--error-bg, #fef2f2);
    color: var(--error-text, #dc2626);
    font-size: 0.625rem;
    font-weight: 700;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
}

[data-page="biologics"] .warning-list .note {
    color: var(--text-muted);
    font-size: 0.8125rem;
}

/* Guidance items (sick days, travel, review) */
[data-page="biologics"] .guidance-item {
    padding: 0.625rem 0;
    border-bottom: 1px solid var(--border-subtle);
}

[data-page="biologics"] .guidance-item:last-child {
    border-bottom: none;
    padding-bottom: 0;
}

[data-page="biologics"] .guidance-item strong {
    display: block;
    color: var(--text-primary);
    font-weight: 600;
    margin-bottom: 0.25rem;
}

[data-page="biologics"] .guidance-item p {
    margin: 0;
    font-size: 0.875rem;
}

/* Info actions (PDF button) */
[data-page="biologics"] .info-actions {
    display: flex;
    gap: 0.75rem;
    margin-top: 1rem;
    padding-top: 1rem;
    border-top: 1px solid var(--border-subtle);
}

[data-page="biologics"] .info-actions .btn {
    flex: 1;
}


/* ===========================================
   6. MOBILE RESPONSIVE
   =========================================== */

@media (max-width: 899px) {
    [data-page="biologics"] .page-content {
        padding: 1rem;
        padding-top: calc(var(--header-height-mobile) + env(safe-area-inset-top, 0px) + 1.5rem);
    }

    /* First card accent border on mobile - matches DMARD pattern */
    [data-page="biologics"] .page-content > .card:first-child,
    .biologics-mobile-card {
        border-top: 3px solid var(--active-color);
        transition: border-top-color 200ms ease-out;
    }

    /* Tighter header spacing on mobile */
    .biologics-card .card-header {
        margin-bottom: 0.5rem;
        padding-bottom: 0.5rem;
    }

    .biologics-section-label {
        margin-bottom: 0.5rem;
    }

    /* 4-column grid on mobile (tablets), 2-column on phones */
    .biologics-class-grid {
        grid-template-columns: repeat(4, 1fr);
        gap: 0.375rem;
    }

    /* Phone: 2-column grid (4 rows of 2) */
    @media (max-width: 480px) {
        .biologics-class-grid {
            grid-template-columns: repeat(2, 1fr);
        }
    }

    .biologics-class-btn {
        padding: 0.5rem 0.25rem;
        height: 44px;
    }

    /* Mobile: show abbreviation only, hide full name */
    .biologics-class-btn .class-name {
        display: none;
    }

    .biologics-class-btn .class-abbrev {
        display: block;
        font-weight: 600;
        font-size: 0.8rem;
    }

    .biologics-drug-grid .select-btn {
        flex: 1;
        min-width: 0;
        height: 52px;
        padding: 0.625rem 0.25rem;
        font-size: 0.8rem;
        font-weight: 700;
        border-radius: var(--radius-sm);
        position: relative;
        transition: all 0.25s cubic-bezier(0.4, 0, 0.2, 1);
    }

    /* Mobile: show top-level abbreviation (hidden by default) */
    .biologics-drug-grid .select-btn > .drug-abbrev {
        display: block;
        color: var(--text-primary);
        font-weight: 700;
    }

    /* Single-drug class: constrain width and center (unless expanded) */
    .biologics-drug-grid:has(.select-btn:only-child) .select-btn:not(.expanded) {
        max-width: 160px;
        margin: 0 auto;
    }

    .biologics-drug-grid .select-btn.selected > .drug-abbrev {
        color: white;
    }

    /* Hide desktop-only elements on mobile */
    .biologics-drug-grid .select-btn .drug-card-content,
    .biologics-drug-grid .select-btn .route-expansion {
        display: none;
    }

    /* Patient mode mobile */
    .biologics-patient-mode {
        padding: 1rem;
    }

    .biologics-patient-summary {
        position: sticky;
        top: calc(var(--header-height-mobile) + env(safe-area-inset-top, 0px));
        z-index: 10;
        margin: -1rem -1rem 1rem -1rem;
        border-radius: 0;
        border-left: none;
        border-top: 3px solid var(--active-color);
    }

    .biologics-schedule-actions {
        flex-direction: column;
    }

    .biologics-schedule-actions .btn {
        width: 100%;
    }

    /* ===========================================
       MOBILE FOCUS-EXPAND PATTERN (Dual-route drugs)
       Performance-optimized: GPU-only animations
       =========================================== */

    /* Isolate layout recalculations */
    .biologics-drug-grid {
        contain: layout style;
    }

    /* Base card: GPU-accelerated transitions only */
    .biologics-drug-grid .select-btn {
        transform: translateZ(0); /* Force GPU layer */
        backface-visibility: hidden;
        transition:
            transform 0.2s cubic-bezier(0.4, 0, 0.2, 1),
            opacity 0.15s ease-out,
            background-color 0.15s ease-out,
            border-color 0.15s ease-out,
            box-shadow 0.2s ease-out;
    }

    /* Prep for animation - hint to browser */
    .biologics-drug-grid .select-btn.has-routes {
        will-change: transform, opacity;
    }

    /* Route indicator dot */
    .biologics-drug-grid .select-btn .route-dot {
        display: block;
        position: absolute;
        top: 5px;
        right: 5px;
        width: 12px;
        height: 12px;
        border-radius: 50%;
        background: linear-gradient(135deg, var(--route-sc) 50%, var(--route-iv) 50%);
        border: 2px solid rgba(255, 255, 255, 0.9);
        box-shadow:
            0 0 0 1px rgba(0, 0, 0, 0.15),
            0 2px 4px rgba(0, 0, 0, 0.2);
        opacity: 1;
        transition: opacity 0.1s ease-out;
    }

    .biologics-drug-grid .select-btn[data-selected-route="SC"] .route-dot {
        background: var(--route-sc);
    }

    .biologics-drug-grid .select-btn[data-selected-route="IV"] .route-dot {
        background: var(--route-iv);
    }

    .biologics-drug-grid .select-btn.expanded .route-dot {
        opacity: 0;
    }

    /* ===== SLIDE-AWAY: GPU-only fade + scale ===== */
    .biologics-drug-grid .select-btn.slide-away {
        opacity: 0;
        transform: translateZ(0) scale(0.85);
        pointer-events: none;
        /* Instant layout collapse - no animation on these */
        position: absolute;
        visibility: hidden;
    }

    /* ===== EXPANDED STATE ===== */
    /* Container gets focus-mode class for instant layout switch */
    .biologics-drug-panel.focus-mode .biologics-drug-grid {
        display: block; /* Switch from flex to block for simpler layout */
    }

    .biologics-drug-grid .select-btn.expanded {
        /* Layout - instant, no transition */
        display: flex;
        flex-direction: column;
        align-items: stretch;
        width: 100%;
        height: auto; /* Override fixed 52px to allow content expansion */
        padding: 0.875rem 1rem;
        border-radius: var(--radius-lg);
        border-left-width: 4px;
        cursor: default;
        /* GPU-animated properties */
        transform: translateZ(0) scale(1);
        box-shadow: var(--shadow-lg);
    }

    /* Abbreviation: instant hide */
    .biologics-drug-grid .select-btn.expanded > .drug-abbrev {
        display: none;
    }

    /* Expanded content: fade in */
    .biologics-drug-grid .select-btn .mobile-expanded-content {
        display: none;
        flex-direction: column;
        gap: 0.75rem;
        width: 100%;
        opacity: 0;
        transform: translateZ(0);
    }

    .biologics-drug-grid .select-btn.expanded .mobile-expanded-content {
        display: flex;
        animation: fadeInContent 0.15s ease-out 0.05s forwards;
    }

    @keyframes fadeInContent {
        from { opacity: 0; transform: translateZ(0) translateY(4px); }
        to { opacity: 1; transform: translateZ(0) translateY(0); }
    }

    /* Header row in expanded state */
    .mobile-expanded-header {
        display: flex;
        align-items: center;
        justify-content: space-between;
    }

    .mobile-expanded-drug-info {
        display: flex;
        align-items: center;
        gap: 0.5rem;
    }

    .mobile-expanded-name {
        font-weight: 700;
        font-size: 1rem;
        color: var(--active-color);
    }

    .mobile-expanded-abbrev {
        font-family: var(--font-mono);
        font-size: 0.65rem;
        font-weight: 600;
        color: var(--text-muted);
        background: var(--bg-page);
        padding: 0.125rem 0.375rem;
        border-radius: 4px;
    }

    /* When card is selected, adjust expanded text colors */
    .biologics-drug-grid .select-btn.selected .mobile-expanded-name {
        color: white;
    }

    .biologics-drug-grid .select-btn.selected .mobile-expanded-abbrev {
        background: rgba(255, 255, 255, 0.15);
        color: rgba(255, 255, 255, 0.7);
    }

    /* Dismiss button */
    .mobile-dismiss-btn {
        display: flex;
        align-items: center;
        justify-content: center;
        width: 32px;
        height: 32px;
        border: 1px solid var(--border-color);
        border-radius: 50%;
        background: var(--bg-page);
        color: var(--text-secondary);
        cursor: pointer;
        transition: all var(--timing-fast);
        flex-shrink: 0;
        -webkit-tap-highlight-color: transparent;
    }

    .mobile-dismiss-btn:active {
        background: var(--bg-card);
        border-color: var(--text-muted);
        color: var(--text-primary);
    }

    .mobile-dismiss-btn:focus-visible {
        outline: none;
        box-shadow: var(--shadow-focus);
    }

    .mobile-dismiss-btn svg {
        width: 16px;
        height: 16px;
    }

    /* When card is selected, dismiss button adapts */
    .biologics-drug-grid .select-btn.selected .mobile-dismiss-btn {
        border-color: rgba(255, 255, 255, 0.3);
        background: rgba(255, 255, 255, 0.1);
        color: rgba(255, 255, 255, 0.8);
    }

    .biologics-drug-grid .select-btn.selected .mobile-dismiss-btn:active {
        background: rgba(255, 255, 255, 0.2);
        color: white;
    }

    /* Mobile route options */
    .mobile-route-options {
        display: flex;
        gap: 0.5rem;
    }

    /* Unified route option buttons (matches dismiss button style) */
    .mobile-route-option {
        flex: 1;
        display: flex;
        align-items: center;
        justify-content: center;
        gap: 0.5rem;
        height: 48px;
        border-radius: var(--radius-md);
        background: rgba(255, 255, 255, 0.12);
        border: 1px solid rgba(255, 255, 255, 0.25);
        color: white;
        cursor: pointer;
        transition: all 0.15s ease;
        font-family: var(--font-mono);
        font-size: 1rem;
        font-weight: 700;
        -webkit-tap-highlight-color: transparent;
    }

    .mobile-route-option:focus-visible {
        outline: none;
        box-shadow: 0 0 0 3px rgba(255, 255, 255, 0.3);
    }

    .mobile-route-option:active {
        background: rgba(255, 255, 255, 0.2);
        border-color: rgba(255, 255, 255, 0.4);
        transform: scale(0.98);
    }

    /* Route indicator dot */
    .route-indicator {
        width: 12px;
        height: 12px;
        border-radius: 50%;
        border: 2px solid rgba(255, 255, 255, 0.9);
        box-shadow:
            0 0 0 1px rgba(0, 0, 0, 0.15),
            0 1px 3px rgba(0, 0, 0, 0.2);
    }

    .route-indicator.sc {
        background: var(--route-sc);
    }

    .route-indicator.iv {
        background: var(--route-iv);
    }

    /* Selection confirmation animation */
    @keyframes mobileSelectionPulse {
        0% { transform: scale(1); }
        50% { transform: scale(0.96); }
        100% { transform: scale(1); }
    }

    .mobile-route-option.confirming {
        animation: mobileSelectionPulse 0.15s ease-out;
    }

    /* Hide section label when in focus mode */
    .biologics-drug-panel.focus-mode .biologics-drug-panel-label {
        opacity: 0;
        transform: translateZ(0) translateY(-8px);
        pointer-events: none;
        transition: opacity 0.15s ease-out, transform 0.15s ease-out;
    }

    /* Clear will-change after animation settles */
    .biologics-drug-panel:not(.focus-mode) .select-btn {
        will-change: auto;
    }
}

/* Mobile: Vertical timeline with duration badge on right */
@media (max-width: 480px) {
    [data-page="biologics"] .timeline-wrapper {
        display: grid;
        grid-template-columns: auto 1fr;
        gap: 0 1rem;
        align-items: start;
        margin-bottom: 1rem;
    }

    [data-page="biologics"] .process-timeline {
        grid-column: 1;
        grid-row: 1;
        flex-direction: column;
        align-items: flex-start;
        gap: 0;
        padding: 0;
        margin: 0;
    }

    /* Line connects center of first to center of last circle */
    /* Account for step padding (6px) + half circle height (15px) = 21px */
    [data-page="biologics"] .timeline-track {
        top: 21px;
        bottom: 21px;
        left: 14px;
        right: auto;
        width: 2px;
        height: auto;
    }

    [data-page="biologics"] .timeline-step {
        flex-direction: row;
        align-items: center;
        gap: 0.75rem;
        padding: 0.375rem 0;
    }

    [data-page="biologics"] .step-marker {
        margin-bottom: 0;
        flex-shrink: 0;
    }

    [data-page="biologics"] .step-label {
        text-align: left;
    }

    /* Duration box positioned to right of timeline */
    [data-page="biologics"] .timeline-duration {
        grid-column: 2;
        grid-row: 1;
        justify-self: end;
        align-self: center;
        display: flex;
        flex-direction: column;
        align-items: center;
        text-align: center;
        white-space: nowrap;
        background: var(--bg-elevated);
        border: 1px solid var(--border-color);
        border-radius: var(--radius-sm);
        padding: 0.5rem 0.75rem;
        margin-left: 1rem;
        font-size: 0.75rem;
    }

    [data-page="biologics"] .timeline-duration svg {
        display: none;
    }

    [data-page="biologics"] .timeline-duration strong {
        display: block;
        color: var(--text-muted);
        text-decoration: underline;
        text-decoration-color: var(--active-color);
        text-underline-offset: 2px;
    }
}

@media (max-width: 600px) {
    .biologics-schedule-table th,
    .biologics-schedule-table td {
        padding: 0.625rem 0.75rem;
    }
}


/* ===========================================
   7. REDUCED MOTION
   =========================================== */

@media (prefers-reduced-motion: reduce) {
    /* Desktop QR panel */
    .qr-output-panel .qr-placeholder,
    .qr-output-panel .qr-placeholder-icon {
        animation: none;
        opacity: 0.5;
    }

    .qr-output-panel.qr-ready .qr-content {
        animation: none;
    }

    .qr-output-panel.qr-ready #biologics-qr-container {
        animation: none;
    }

    /* Mobile QR section */
    .qr-placeholder-mobile,
    .qr-placeholder-mobile .qr-placeholder-icon {
        animation: none;
        opacity: 0.5;
    }

    .biologics-mobile-card.qr-ready #biologics-qr-container {
        animation: none;
    }

    /* Remove glows in reduced motion */
    .qr-output-panel.qr-ready[data-active-class] #biologics-qr-container,
    .biologics-mobile-card.qr-ready[data-active-class] #biologics-qr-container {
        box-shadow: var(--shadow-sm) !important;
    }

    /* Timeline pulse animation */
    [data-page="biologics"] .timeline-step.active .step-marker {
        animation: none;
        box-shadow: 0 0 0 4px var(--active-glow);
    }

    /* General */
    .biologics-drug-panel {
        animation: none;
    }

    .biologics-class-btn,
    .select-btn {
        transition: none;
    }

    /* Mobile focus-expand pattern */
    .biologics-drug-grid .select-btn {
        transition: none !important;
    }

    .biologics-drug-grid .select-btn.expanded .mobile-expanded-content {
        animation: none;
        opacity: 1;
    }

    .mobile-route-option.confirming {
        animation: none;
    }

    .biologics-drug-panel.focus-mode .biologics-drug-panel-label {
        transition: none;
    }
}